Lesson Overview Mutaons) Types of Mutations Now and then cells make mistakes in copying their own DNA, inserting the wrong base or even skipping a base as a strand is put
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13.3 Mutations KeyQuestions: 1) What are mutations? 2) How do mutations affect genes? The sequence of bases in DNA are like the letters of a coded message
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Vocabulary • Mutation – Point 2 – Frameshift – Chromosomal • Mutagen Key Concepts: •What are the different kinds of mutations that can occur in DNA?
13.3 Mutations I. Go to www.biology.com and login using Bainbridge/biology#1. Click on Explore, Unit 4 Genetics, Chapter 13 RNA & Protein Synthesis, 13.3 Mutations,
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Mutations Worksheet Name: _____ANSWER KEY____ Date: ____10-8-08____Block:__2nd/3rd___ There are three main types of mutations: point missense mutations, point
Worksheet 13.3: Mutations ... Point Mutations Substitution insertion deletion substitution. Complete the following sentences by using the terms in the box found in
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Worksheet 13.3: Mutations ... Point Mutations Substitution insertion deletion substitution. Complete the following sentences by using the terms in the box found in
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13.3 Mutations Types of Mutations For Questions 1–8, match the term with its definition. Definition
Term
1. The change of one base to another in a DNA sequence
A. mutation
2. A change in one or a few nucleotides that occur at a single point in the DNA sequence
B. substitution
3. Part of one chromosome breaks off and attaches to another
C. point mutation D. frameshift mutation E. insertion
4. A heritable change in genetic information 5. A mutation that produces an extra copy of all or part of a chromosome 6. A chromosomal mutation that reverses the direction of parts of a chromosome
F. translocation G. inversion H. duplication
7. A kind of mutation that can change every amino acid that follows the point of mutation 8. The addition of a base to the DNA sequence
9. Complete the table to describe the processes and outcomes of the different types of gene (point) mutations.
Type Substitution
Insertion
Deletion
Description
Outcome
10. Deletion can happen as a gene mutation or as a chromosomal mutation. What is the difference?
Effects of Mutations For Questions 10–17, write the letter of the correct answer on the line at the left. 10. The cellular machinery that replicates DNA inserts an incorrect base A. most of the time. B. about half the time. C. roughly once in every million bases. D. roughly once in every 10 million bases. 11. A possible mutagen is A. an anticodon. B. translocation. C. hemoglobin. D. ultraviolet light. 12. What happens when cells cannot repair the damage caused by a mutagen? A. The DNA base sequence changes permanently. B. The DNA base sequence is not affected. C. The organism is not affected. D. The organism is affected temporarily. 13. Which of the following most accurately summarizes the effects of mutations on living things? A. Most mutations are harmful, but some have little effect. B. Many mutations have little or no effect, but some can be harmful or beneficial. C. Most mutations are beneficial and a few are harmful. D. About half of mutations are beneficial and half are harmful. 14. Mutations are important to the evolution of a species because they A. happen over the long period of time that evolution requires. B. cut out and replace damaged or useless genes. C. are a source of genetic variability. D. accelerate the transcription rate of DNA. 15. Cancer is the product of a mutation that A. causes the uncontrolled growth of cells. B. changes the structure of hemoglobin in the blood. C. brings about stunted growth and severe pain. D. causes a translocation in a pair of chromosomes. 16. Polyploidy is the condition in which A. a piece of a chromosome breaks off and reattaches to another chromosome. B. an organism has an extra set of chromosomes. C. a mutagen speeds the mutation rate. D. an insect develops a resistance to a pesticide.
