CHAPTER 6: THE SKELETAL SYSTEM
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SKELETAL CARTILAGE
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Figure 6.1 The bones and cartilages of the human skeleton.
Cartilage in external ear
Cartilage in Intervertebral disc
Cartilages in nose Articular Cartilage of a joint
Epiglottis Thyroid cartilage Cricoid cartilage
Larynx Trachea Lung
Costal cartilage
Respiratory tube cartilages in neck and thorax Pubic symphysis Meniscus (padlike cartilage in knee joint) Articular cartilage of a joint
Bones of skeleton Axial skeleton Appendicular skeleton
Cartilages Hyaline cartilages Elastic cartilages
Fibrocartilages Copyright © 2010 Pearson Education, Inc.
GROWTH OF CARTILAGE
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Intervertebral discs are made of which type of cartilage? 1) Elastic cartilage 2) Fibrocartilage 3) Hyaline cartilage
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BONE CLASSIFICATION
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AXIAL VS. APPENDICULAR
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Figure 6.1 The bones and cartilages of the human skeleton.
Cartilage in external ear
Cartilage in Intervertebral disc
Cartilages in nose Articular Cartilage of a joint
Epiglottis Thyroid cartilage Cricoid cartilage
Larynx Trachea Lung
Costal cartilage
Respiratory tube cartilages in neck and thorax Pubic symphysis Meniscus (padlike cartilage in knee joint) Articular cartilage of a joint
Bones of skeleton Axial skeleton Appendicular skeleton
Cartilages Hyaline cartilages Elastic cartilages
Fibrocartilages Copyright © 2010 Pearson Education, Inc.
Figure 6.2 Classification of bones on the basis of shape.
(a) Long bone (humerus)
(b) Irregular bone (vertebra), right lateral view Copyright © 2010 Pearson Education, Inc.
(c) Flat bone (sternum)
(d) Short bone (talus)
FUNCTIONS OF BONES
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True or false: Every bone has the same primary functions. 1) True 2) False
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BONE STRUCTURE GROSS STRUCTURE
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Figure 6.3 The structure of a long bone (humerus of arm).
Articular cartilage
Proximal epiphysis
Compact bone Spongy bone Epiphyseal line Periosteum Compact bone Medullary cavity (lined by endosteum)
Diaphysis
Endosteum
(b) Yellow bone marrow Compact bone Periosteum Perforating (Sharpey’s) fibers Nutrient arteries
Distal epiphysis (a) Copyright © 2010 Pearson Education, Inc.
(c)
Figure 6.5 Flat bones consist of a layer of spongy bone sandwiched between two thin layers of compact bone.
Spongy bone (diploë) Compact bone
Trabeculae
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The connective tissue surrounding a bone is called the… 1) 2) 3) 4)
Diaphysis Endosteum Epiphysium Periosteum
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True or false: Trabeculae are found in compact bone. 1) True 2) False
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BONE STRUCTURE MICROSCOPIC ANATOMY
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Figure 6.4 Comparison of different types of bone cells.
(a) Osteogenic cell
(b) Osteoblast
(c) Osteocyte
(d) Osteoclast
Stem cell
Matrix-synthesizing cell responsible for bone growth
Mature bone cell that maintains the bone matrix
Bone-resorbing cell
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Figure 6.6 A single osteon.
Structures in the central canal
Artery with capillaries Vein Nerve fiber Lamellae Collagen fibers run in different directions
Twisting force Copyright © 2010 Pearson Education, Inc.
Figure 6.7 Microscopic anatomy of compact bone. Spongy bone
Compact bone
Central (Haversian) canal
Perforating (Volkmann’s) canal Endosteum lining bony canals and covering trabeculae
Osteon (Haversian system) Circumferential lamellae
(a) Perforating (Sharpey’s) fibers Lamellae
Nerve Vein Artery Canaliculi Osteocyte in a lacuna (b) Copyright © 2010 Pearson Education, Inc.
Periosteal blood vessel Periosteum
Lamellae Central canal Lacunae
Lacuna (with osteocyte) (c)
Interstitial lamellae
The cells which build new bone are: 1) 2) 3) 4)
Osteoblasts Osteogenic cells Osteoclasts Osteocytes
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Osteocytes receive their nutrition from fluid in the ________, which are connected to the larger ___________. 1) Canaliculi / central canal 2) Lamellae / lacunae 3) Osteoblasts / lacunae
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BONE STRUCTURE CHEMICAL COMPOSITION OF BONE
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Hydroxyapatite is part of the _______ component of bone. 1) Cellular 2) Organic 3) Inorganic
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OSTEOGENESIS INTRAMEMBRANOUS OSSIFICATION
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Figure 6.8 Intramembranous ossification. Mesenchymal cell Collagen fiber Ossification center
Osteoid
Osteoblast Osteoid Osteocyte Newly calcified bone matrix
Osteoblast 1 Ossification centers appear in the fibrous connective tissue membrane. • Selected centrally located mesenchymal cells cluster and differentiate into osteoblasts, forming an ossification center.
Mesenchyme condensing to form the periosteum Trabeculae of woven bone Blood vessel
2 Bone matrix (osteoid) is secreted within the fibrous membrane and calcifies. • Osteoblasts begin to secrete osteoid, which is calcified within a few days. • Trapped osteoblasts become osteocytes.
Fibrous periosteum Osteoblast Plate of compact bone Diploë (spongy bone) cavities contain red marrow
4 Lamellar bone replaces woven bone, just deep to 3 Woven bone and periosteum form. the periosteum. Red marrow appears. • Accumulating osteoid is laid down between embryonic blood vessels in a random manner. The result is a network • Trabeculae just deep to the periosteum thicken, and are later replaced with mature lamellar bone, forming compact bone (instead of lamellae) of trabeculae called woven bone. • Vascularized mesenchyme condenses on the external face plates. • Spongy bone (diploë), consisting of distinct trabeculae, perof the woven bone and becomes the periosteum. sists internally and its vascular tissue becomes red marrow. Copyright © 2010 Pearson Education, Inc.
OSTEOGENESIS ENDOCHONDRIAL OSSIFICATION
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Figure 6.9 Endochondral ossification in a long bone. Month 3
Week 9
Birth
Childhood to adolescence Articular cartilage
Secondary ossification center Epiphyseal blood vessel
Area of deteriorating cartilage matrix Hyaline cartilage
1 Bone collar
Epiphyseal plate cartilage
Spongy bone formation
Bone collar Primary ossification center
Medullary cavity
Blood vessel of periosteal bud
2 Cartilage in the
3 The periosteal
center of the forms around hyaline cartilage diaphysis calcifies and then develops model. cavities.
bud invades the internal cavities and spongy bone begins to form.
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Spongy bone
4 The diaphysis elongates
and a medullary cavity forms as ossification continues. Secondary ossification centers appear in the epiphyses in preparation for stage 5.
5 The epiphyses
ossify. When completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages.
The starting point for endochondrial ossification is called the… 1) 2) 3) 4)
Medullary cavity Periosteal bud Primary ossification center Bone collar
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POSTNATAL BONE GROWTH AND REMODELING
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Figure 6.10 Growth in length of a long bone occurs at the epiphyseal plate.
Resting zone
1 Proliferation zone
Cartilage cells undergo mitosis. 2 Hypertrophic zone
Older cartilage cells enlarge. Calcified cartilage spicule Osteoblast depositing bone matrix Osseous tissue (bone) covering cartilage spicules Copyright © 2010 Pearson Education, Inc.
Calcification zone Matrix becomes calcified; cartilage cells die; matrix begins deteriorating. 3
Ossification zone New bone formation is occurring. 4
Figure 6.11 Long bone growth and remodeling during youth.
Bone growth
Cartilage grows here.
Bone remodeling
Articular cartilage
Epiphyseal plate
Cartilage is replaced by bone here. Cartilage grows here. Cartilage is replaced by bone here.
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Bone is resorbed here. Bone is added by appositional growth here. Bone is resorbed here.
Growth of bone length is due largely to increasing numbers of cells in the _______ zone… 1) 2) 3) 4)
calcification hypertrophic ossification proliferation
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CONTROL OF BONE REMODELING
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Figure 6.12 Parathyroid hormone (PTH) control of blood calcium levels.
Calcium homeostasis of blood: 9–11 mg/100 ml BALANCE BALANCE
Stimulus
Falling blood Ca2+ levels
Thyroid gland Osteoclasts degrade bone matrix and release Ca2+ into blood. Copyright © 2010 Pearson Education, Inc.
Parathyroid glands PTH
Parathyroid glands release parathyroid hormone (PTH).
Figure 6.13 Bone anatomy and bending stress.
Load here (body weight)
Head of femur
Tension here
Compression here Point of no stress
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Which of the following does NOT control bone growth or remodeling?
1) 2) 3) 4) 5)
Growth hormone Mechanical force Parathyroid hormone Thyroid hormone Calcitonin
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FRACTURES
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Table 6.2 Common Types of Fractures (1 of 3)
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Table 6.2 Common Types of Fractures (2 of 3)
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Table 6.2 Common Types of Fractures (3 of 3)
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The type of fracture which commonly occurs in porous bones subjected to a fall is a… 1) 2) 3) 4) 5) 6)
Comminuted fracture Compression fracture Spiral fracture Epiphyseal fracture Depression fracture Greenstick fracture
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BONE REPAIR
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Figure 6.15 Stages in the healing of a bone fracture.
Hematoma
Internal callus (fibrous tissue and cartilage)
1 A hematoma forms.
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External callus
New blood vessels
Bony callus of spongy bone Healed fracture
Spongy bone trabecula
2 Fibrocartilaginous callus forms.
3 Bony callus forms.
4 Bone remodeling occurs.
True or false: if a bone breaks, it bleeds.
1) True 2) False
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HOMEOSTATIC IMBALANCES
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Figure 6.16 The contrasting architecture of normal versus osteporotic bone.
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The disease which causes children to have soft, malformed bones due to vitamin D or calcium deficiency is… 1) Rickets 2) Osteomalacia 3) Osteporosis 4) Paget’s Disease
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FETAL SKELETAL DEVELOPMENT
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Figure 6.17 Fetal primary ossification centers at 12 weeks.
Parietal bone Occipital bone
Mandible
Frontal bone of skull
Clavicle Scapula Radius Ulna
Ribs
Humerus
Vertebra Ilium Tibia Femur
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