Human physiology is the study of the functioning of the normal body, and is responsible for describing how various systems of the human body work
Figure 1. Location of liver in the body. Portal Hypertension: Introduction As early as the 17th century, it was realized that structural changes in the portal
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Standing Order: Antihypertensive Initiation and Titration Divisions: General Internal Medicine
General Internal Medicine Extenders are allowed to initiate and titrate antihypertensive agents per this standing order. The attached algorithm will be used to determine if titration of an existing preferred antihypertensive is necessary, or addition of another preferred agent is needed. The appropriate laboratory tests will be ordered and follow-up will be conducted by the pharmacist according to the attached protocol. Non-preferred agents may be titrated only to optimal doses as listed below. Blood pressure will be reassessed 2-3 weeks after each dosage adjustment. Signature _________________________________ Internal Medicine Clinic Director Updated June 9, 2005 Equivalency Chart for ACE-Inhibitors (Preferred Agents): Benazepril 10 mg Enalapril 5 mg (Optimal 20 mg) Captopril 12.5 mg BID Enalapril 5 mg (Optimal 20 mg) Ramipril 2.5 mg Enalapril 5 mg (Optimal 20 mg) Fosinopril 10 mg Enalapril 5 mg (Optimal 20 mg) Lisinopril 10 mg Enalapril 5 mg (Optimal 20 mg) Moexipril 7.5 mg Enalapril 5 mg (Optimal 20 mg) Quinapril 10 mg Enalapril 5 mg (Optimal 20 mg) Trandolapril 1 mg Enalapril 5 mg (Optimal 20 mg) Equivalency Chart for Angiotensin II Blockers (Preferred Agents): Candesartan 8 mg Losartan 25 mg (max=50 mg) Irbesartan 75 mg Losartan 25 mg (max=50 mg) Telmisartan 40 mg Losartan 25 mg (max=50 mg) Valsartan 80 mg Losartan 25 mg (max=50 mg) Equivalency Chart for β-Blockers (Preferred Agents): Betaxolol 10 mg/day Atenolol 50 mg/day Bisoprolol 5 mg/day Atenolol 50 mg/day Metoprolol 100 mg/day Atenolol 50 mg/day Nadolol 40 mg/day Atenolol 50 mg/day Timolol 20 mg/day Atenolol 50 mg/day Doses listed are representative of equivalent doses and should be used to calculate other doses. For example, if a patient comes to clinic on benazepril 20 mg, the equivalent ramipril dose would be 5 mg. Non-Preferred Agent Optimal Dosing Amlodipine Felodipine Verapamil Diltiazem Clonidine Doxazosin
Extender= Registered Nurse, Pharmacist, Nurse Practitioner, or Registered Dietician. Copyright 2005. UNC Center for Excellence in Chronic Illness Care
BP > 140/90 without diabetes BP> 130/80 with diabetes
On ACEi or ARB?
Yes
No
Optimize to ½ maximum dose (Check SCr, K)
Initiate Enalapril 5 mg or equivalent (Check SCr, K)
BP >130/80
BP >130/80
Yes
No Yes
No
Continue current therapy Continue current therapy CAD?
Yes
On Atenolol or equivalent
Yes
On HCTZ?
No
Yes
No
Optimize to 25 mg (Check SCr, K)
Add HCTZ 12.5 to 25 mg (Check SCr, K)
BP >130/80
BP >130/80
Yes
Yes
No
Continue current therapy
No Add Atenolol 12.5 to 25 mg QD
Optimize to HR 60-70 BPM
BP >130/80
BP >130/80 Yes Yes
No
No Continue current therapy
Optimal ACEi/ARB or HCTZ?
Yes
Continue current therapy
No
No
Optimize ACEi/ARB or HCTZ
Titrate non-preferred agent or consult MD Extender= Registered Nurse, Pharmacist, Nurse Practitioner, or Registered Dietician. Copyright 2005. UNC Center for Excellence in Chronic Illness Care
