THE JOURNAL OF CLINICAL INVESTIGATION

Download THE JOURNAL OF CLINICAL INVESTIGATION. Produced by The Rockefeller University Press, New York, for. The American Society for Clinical Inves...

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THE JOURNAL OF CLINICAL INVESTIGATION Produced by The Rockefeller University Press, New York, for The American Society for Clinical Investigation, Inc. PAUL A. MARKS, EDITOR

Associate Editors HARRY W. FRITTS, JR. ZANVIL A. COHN DEWITT S. GOODMAN EDWARD C. FRANKLIN RICHARD M. HAYS

The Editorial Committee of The American Society for Clinical Investigation, Inc. EDWARD H. KASS, Boston, Mass. DAVID V. BATES, Montreal, Canada GRANT W. LIDDLE, Nashville, Tenn. ROBERT W. BERLINER, Bethesda, Md. T. JOSEPH REEVES, Birmingham, Ala. La Jolla, Calif. EUGENE BRAUNWALD, RUDI SCHMID, San Francisco, Calif. NEAL S. BRICKER, St. Louis, Mo. MARVIN D. SIPERSTEIN, Dallas, Tex. Utah Lake Salt City, GEORGE E. CARTWRIGHT, LLOYD H. SMITH, JR., San Francisco, Calif. San RICHARD J. HAVEL, Francisco, Calif. VAUGHAN, Rochester, N. Y. Mass. JOHN HOWARD H. HIATT, Boston, HENRY 0. WHEELER, La Jolla, Calif. THE JOURNAL OF CLINICAL INVESTIGATION publishes original papers on research pertinent to human biology and disease. Work using animals or in vitro techniques is acceptable if it is relevant to human normal or abnormal biology. No substantial part of a paper may have been or may be published elsewhere. Single, complete papers are preferred to a series of interdependent ones. It is assumed that all clinical investigation described in manuscripts submitted to this JOURNAL shall have been conducted according to the principles expressed in the Declaration of Helsinki, which has been endorsed by The American Society for Clinical Investigation, Inc. (see Vol. 46, p. 1140). Manuscripts are published in the order of final acceptance after review and revision. Papers requiring much editing will be delayed until they are in good form. For information on preparation of manuscripts, see Instructions to Authors published in the January issue. Submit manuscripts in two complete sets, plus a third copy of the abstract, to: Dr. Paul A. Marks, Editor THE JOURNAL OF CLINICAL INVESTIGATION

Columbia University College of Physicians & Surgeons 630 West 168th Street New York 10032

The author will be charged $20 per page of his printed article, provided research grants or institutional funds can bear this cost. Authors may purchase reprints at prices furnished with galley proof. Others desiring reprints should

write the authors, not the JOURNAL. Claims for

copies lost in the mails must be received within 30 days (domestic) or 90 days (foreign) of the date of issue. Changes of address must be received at least 2 weeks in advance of the date of issue. Each volume consists of 12 monthly issues. The rate for both foreign and domestic subscriptions is $30 per volume payable in advance and in U. S. funds. Medical students, interns, fellows, and residents of approved hospitals may subscribe at the special rate of $15 per volume. Single copies are $2.75 a copy. There is no charge for postage. Remit by draft or check on New York, or by postal money order, payable to THE JOURNAL OF CLINICAL INVESTIGATION, The Rockefeller University Press, Post Office Box 5108, Church Street Station, New York 10008. Address correspondence about subscriptions and manuscripts in press to: THE JOURNAL OF CLINICAL INVESTIGATION

The Rockefeller University Press New York 10021

Copyright © 1969, The American Society for Clinical Investigation, Inc.