Physical Sciences Inc.
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Biomedical Optics Instrumentation Dan Hammer, Dan Ferguson, Nick Iftimia, Dave Rosen Physical Sciences Inc. A Case Study for University – Industry Collaboration presented by Mark Druy and B. David Green at the
Session on SBIR Successes at 2010 National SBIR Beyond Phase II Conference and Technology Showcase 15 September 2010 Physical Sciences Inc.
20 New England Business Center
Andover, MA 01810
Who we are Physical Sciences Inc.
A growing 37 year-old company of 180 scientists, engineers and administrative professionals
Headquartered in Andover, MA; operations in: – – – – –
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Pleasanton, CA (PSI) Lanham, MD and Princeton, NJ (RSI) Bedford, MA (Q-Peak) Dayton, OH (Faraday Technology) College Park, MD (Maxion Technologies)
Research Support Instruments supports the Naval Research Laboratory and National programs
Q-Peak manufactures lasers and optical devices
Faraday Technology develops electrochemical processing
Maxion Technologies develops long-wavelength (3-12 microns) infrared semiconductor lasers
PSI is a technologically diverse research and development organization with revenues of $50+M
Owned by the PSI Employee Stock Ownership Trust
Our Locations Physical Sciences Inc. VG10-182-2
Andover, MA
Pleasanton, CA PSI Space Exploration Technologies and Novel Electro-optic Materials
Corporate Headquarters PSI Main Offices
Haverhill, MA
Material Sciences and Technologies, Optics and Laser Technologies, Space and Atmospheric Studies, Energy Technologies
Advanced Composite Structures
PSI
Bedford, MA Q-Peak Solid State Lasers Princeton, NJ RSI MEMS and Plasma Technologies Lanham, MD RSI Systems Support and Calibration College Park, MD Maxion Technologies, Inc. Quantum and Interband Cascade Lasers IR EO Materials and Devices Clayton, OH Faraday Technology, Inc.
Pulsed/Pulse Reverse Electrochemical Engineering for Precise Surface Modification C-7543
Creating Value For Our Customers Physical Sciences Inc. VG10-182-3
Leading edge technology invention, development, and application Custom instrument development Prototype product development, premanufacturing, and technology transfer Production of specialized instruments Technology and product licensing to strategic partners and spin-outs
Army, Air Force, and NIH SBIR/STTR Funding has led to
Physical Sciences Inc.
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Rapid assessment tool for retinal damage from laser illumination
Tools for angiography and guided surgery in the eye
Biomedical optical systems for ophthalmic researchers, clinicians, and other medical personnel – Detection of diseases – Discovery of novel therapies – Understanding of the body from system/organ to sub-cellular and molecular structures
PSI (small business) creating improved diagnostic instrumentation – Eye diseases, eye health, drug discovery
University – Teaching hospital – Industry collaborative research – Publications motivating additional research by many groups around world
Sale of advanced instrumentation to leading research labs
Licensing of technology to leading established OCT manufacturer – Wide spread application in clinics and laboratories
Licensing of enabling technology to several focused start up companies – Many formed from university labs
Ophthalmic Diagnostics Physical Sciences Inc. VG10-182-5
Ophthalmic Instrumentation – – – –
TSO: Tracking, Scanning Ophthalmoscope TOCT: Tracking Optical Coherence Tomography LSO: Line Scanning Ophthalmoscope AOSLO: Adaptive Optics Scanning Laser Ophthalmoscope
Applications – Laser illumination damage and mechanisms – Diagnosis and surgical guidance in the eye – Degenerative eye diseases in children and aged • Diabetic retinopathy, macular degeneration – Research on the cellular basis of eye diseases
Biomedical Imaging Instruments Physical Sciences Inc.
Line scanning ophthalmoscopy (LSO) – Compact retinal imager to augment or guide OCT • Autofluorescence, microperimetry • Small animal imaging and advanced therapies – patents – 5 licenses with ophthalmic instrument manufacturers Retinal tracking (TOCT) – High-speed, high fidelity stabilization of eye motion – Applications: AO, SDOCT, PSOCT, hemodynamics – Diagnostic or therapeutic beams – > 12 systems sold to researchers – patents Adaptive optics (AOSLO) – Measurement and correction of ocular aberrations – Ultrahigh resolution of retinal structures – patent applications Real-time Fourier domain OCT processor
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Collaborators Physical Sciences Inc. VG10-182-7
Including:
Institutions:
Bruce Stuck Henry Hacker Ben Rockwell David R. Williams Benjamin Bloom T. Milner Robb Webb Ann Elsner Steve Burns Johannes F. de Boer Joel Schuman
Army Medical Research Branch Air Force Research Lab HPW, Brooks Schepens Eye Research Institute Mass Eye and Ear Infirmary MIT University of Pittsburgh University of Rochester University of Texas, Austin Indiana University Massachusetts General Hospital Boston Medical Center Brigham and Women’s Hospital University of Texas Medical Branch
Representative Journal Publications Physical Sciences Inc.
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Applied Optics: Compact Scanning Laser Ophthalmoscope with High-Speed Retinal Tracker Optics Express: Image Stabilization for Scanning Laser Ophthalmoscope Journal of Biomedical Optics: An Active Retinal Tracker for Clinical Optical Coherence Tomography Systems Optics Express: Advanced Scanning Methods with Tracking Optical Coherence Tomography Journal of Biomedical Optics:Scanning Laser Opthalmoscope Optics Express: Wide-field hemodynamic imaging with tracking ophthalmoscope Optics Express: Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging Journal of the Optical Society of America: Increased Signal and Resolution with Adaptive Optics Spectral Domain Optical Coherence Tomography
Optics Express: Hybrid retinal imager using linescanning laser ophthalmoscopy and spectral domain optical coherence tomography Optics Letters: Tracking OCT Optics Express: Dual-beam Fourier domain optical Doppler tomography of zebrafish Circulation Research: Blood flow and cardiac output measurements in zebrafish (Danio rerio) using dual-beam Fourier domain optical Doppler tomography Review Scientific Instruments: Realtime processing for Fourier domain optical coherence tomography using a field programmable gate array Optics Express: Compact adaptive optics line scanning Ophthalmoscope Journal of the Optical Society of America A: Adaptive optics SLO with integrated wide-field retinal imaging and tracking
Licenses: Tracking for Ophthalmic Office Market Physical Sciences Inc. VG10-182-9
Partner with major instrument company – Non exclusive license – Transfer technology – Work with development team to incorporate in Gen 4 product
Benefit – Provides high contrast, wide area image of retina – Ensures precise registration between OCT scan and fundus image
Adds incremental cost to product – Significantly greater value
Sold 5940 units in 27 months PSI receives modest royalty income
Custom Instrument Sales to Researchers Physical Sciences Inc.
Licenses to start up companies – commercial product creation – – – – –
retinal metabolic analysis perimetry therapeutics (pending) small animal imaging OCT, optical biometer
Custom ophthalmic instruments for researchers at: – – – – – – – – – – – –
U. Rochester Indiana U. U. Texas Medical Branch U. Texas Austin Harvard MIT U. Pittsburgh Medical Center Mass General Hospital Children’s Hospital/Boston U. Michigan U. Waterloo FDA
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Summary Physical Sciences Inc. VG10-182-12
Under Air Force, Army, and NIH SBIR /STTR funding PSI staff has: – Performed world class research in the understanding and diagnosis of diseases of the eye – Collaborated with many researchers in academia – Published and presented results to community to spur additional research – Obtained six patents – Developed several generations of optical diagnostic technology – Standardized subassemblies and process in a Prototype Manufacturing Area – Offered specialized instruments and sold them to the research community – Created further collaborations and advanced research by the community
Licensing several generations of the technology to companies for commercial products – Established commercial company next product for wide application in clinics – Start up companies for autofluorescence, low cost retinal screening, image-guided therapy • Many grow and evolve from university laboratories
University – PSI Partnerships in Last Five Years Physical Sciences Inc. VG10-182-13
Alfred University Boston University Brown University California State University Cornell University Dartmouth College Duke University Emory University Harvard University Indiana University Iowa State Johns Hopkins University Medical College of Wisconsin
Michigan Tech University MIT Northeastern University Ohio State University Pennsylvania State University Princeton University State University of New York UMass Lowell University of Arizona University of Connecticut University of Deleware University of Denver University of Florida
University of Illinois University of Michigan University of Maryland University of New Hampshire University of North Carolina University of Notre Dame University of Pittsburg University of Rochester University of Texas Utah State University Western New England College West Virginia University Worcester Polytechnic Institute
