This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the articles on therapy from the JAMA s...
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CRITICAL APPRAISAL WORKSHEET 1 AN ARTICLE ON THERAPY This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the articles on therapy from the JAMA series on Users’ Guides to the Medical Literature. Reading these articles should be helpful to you in working through this worksheet as it pertains to your key article(s). Feel free to make photocopies. You can also print off additional copies from the CFPC Web Site ( www.cfpc.ca/cme/pearls/pearlsmain.asp ).
Author(s): Short title: Journal/Year/Volume/ Pages:
A.
ARE THE STUDY RESULTS VALID?
1.
Was the assignment of patients to treatment groups truly randomized?
Yes No Can't tell
2.
Were all patients who entered the study accounted for appropriately at the end?
Yes No Can't tell
i) Is the number randomized the same as in results? (Try a best case/ worse case scenario.) ii) Were patients analysed in the groups they were allocated to at the start of the study?
3.
Were patients, physicians, and those doing the assessments "blind" to treatment?
4.
Was similarity between groups documented? i) Is there a table of baseline characteristics? ii) Were differences controlled for in the analysis?
5.
Aside from the intervention, were the groups treated in the same way?
Yes No Can't tell
Yes No Can't tell
Yes No Can't tell
B.
WHAT WERE THE RESULTS?
1.
How large was the treatment effect?
2.
How precise was the estimate of the treatment effect?
C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?
1.
Can the results be applied to my patient (care)?
Yes No Can't tell
i) Are study patients similar to your patient?
2.
Were all clinically important outcomes reported?
Yes No Can't tell
i) Were the most important outcomes used? ii) Were quality of life outcomes used? Assessment of adverse effects?
3.
Are the likely treatment benefits greater than the potential harms and costs?
Yes No Can't tell
CONCLUSIONS The results or recommendations are valid (from A).
Yes
No
Can’t tell
The results are clinically important (from B).
Yes
No
Can’t tell
The results are relevant to my practice (from C).
Yes
No
Can’t tell
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CRITICAL APPRAISAL WORKSHEET 2 AN ARTICLE ON A DIAGNOSTIC TEST This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the articles on diagnostic tests from the JAMA series on Users’ Guides to the Medical Literature. Reading these articles should be helpful to you in working through this worksheet as it pertains to your key article(s). Feel free to make photocopies. You can also print off additional copies from the CFPC Web Site ( www.cfpc.ca/cme/pearls/pearlsmain.asp ).
Author(s): Short title: Journal/Year/Volume/ Pages:
A.
ARE THE STUDY RESULTS VALID?
1.
Was there an independent "blind" comparison with a reference standard?
Yes No Can't tell
2.
Did the patient sample include an appropriate spectrum of patients to whom the diagnostic test will be applied in clinical practice?
Yes No Can't tell
3.
Did the results of the test being evaluated influence the decision to perform the reference standard?
Yes No Can't tell
4.
Were the methods for performing the test described in sufficient detail to permit replication?
Yes No Can't tell
B. 1.
WHAT WERE THE RESULTS? Consider the pre-test and post-test possibilities.
Yes No Can't tell
i) Are likelihood ratios for the test results presented or data necessary for their calculation provided?
C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?
1.
Will the reproducibility of the test result and its interpretation be satisfactory in my setting?
Yes No Can't tell
2.
Are the results applicable to my patient?
Yes No Can't tell
3.
Will the results change my management?
Yes No Can't tell
4.
Will patients be better off as a result of the test?
Yes No Can't tell
CONCLUSIONS The results or recommendations are valid (from A).
Yes
No
Can’t tell
The results are clinically important (from B).
Yes
No
Can’t tell
The results are relevant to my practice (from C).
Yes
No
Can’t tell
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CRITICAL APPRAISAL WORKSHEET 3 AN ARTICLE ON PROGNOSIS OR HARM This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the articles on prognosis and harm from the JAMA series on Users’ Guides to the Medical Literature. Reading these articles should be helpful to you in working through this worksheet as it pertains to your key article(s). Feel free to make photocopies. You can also print off additional copies from the CFPC Web Site ( www.cfpc.ca/cme/pearls/pearlsmain.asp ).
Author(s): Short title: Journal/Year/Volume/ Pages:
A.
ARE THE STUDY RESULTS VALID?
1.
Was there a representative and well-defined sample of patients at a similar point in the course of the disease?
Yes No Can't tell
2.
Was follow-up sufficiently long and complete?
Yes No Can't tell
3.
Were objective and unbiased outcome criteria used?
Yes No Can't tell
4.
Was there adjustment for important prognostic factors?
Yes No Can't tell
B.
WHAT WERE THE RESULTS?
1.
How large is the likelihood of the outcome event(s) in a specific period of time?
2.
How precise are the estimates of likelihood? (Consider 95% C.I.)
C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?
1.
Were the study patients similar to my own?
Yes No Can't tell
2.
Are the results useful for reassuring or counselling patients?
Yes No Can't tell
CONCLUSIONS The results or recommendations are valid (from A).
Yes
No
Can’t tell
The results are clinically important (from B).
Yes
No
Can’t tell
The results are relevant to my practice (from C).
Yes
No
Can’t tell
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CRITICAL APPRAISAL WORKSHEET 4 AN OVERVIEW, REVIEW OR META ANALYSIS ARTICLE This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the article on overviews from the JAMA series on Users’ Guides to the Medical Literature. Reading this article should be helpful to you in working through this worksheet as it pertains to your key article(s). Feel free to make photocopies. You can also print off additional copies from the CFPC Web Site ( www.cfpc.ca/cme/pearls/pearlsmain.asp ).
Author(s): Short title: Journal/Year/Volume/ Pages:
A.
ARE THE STUDY RESULTS VALID?
1.
Did the overview address a focused clinical question?
Yes No Can't tell
2.
Were the criteria used to select articles for inclusion appropriate?
Yes No Can't tell
3.
Is it unlikely that important relevant studies were missed?
Yes No Can't tell
4.
Was the validity of the included studies appraised?
Yes No Can't tell
5.
Were assessments of studies reproducible?
Yes No Can't tell
6.
Were the results similar from study to study?
Yes No Can't tell
B.
WHAT WERE THE RESULTS?
1.
What are the overall results of the review?
2.
How precise were the results?
C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?
1.
Can the results be applied to my patient (care)?
Yes No Can't tell
2.
Were all clinically important outcomes considered?
Yes No Can't tell
3.
Are the benefits worth the harms and costs?
Yes No Can't tell
CONCLUSIONS The results or recommendations are valid (from A).
Yes
No
Can’t tell
The results are clinically important (from B).
Yes
No
Can’t tell
The results are relevant to my practice (from C).
Yes
No
Can’t tell
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CRITICAL APPRAISAL WORKSHEET 5 A CLINICAL PRACTICE GUIDELINE This worksheet should be submitted along with the completed Submission Form to your supervisor. It is based on the articles on clinical practice guidelines from the JAMA series on Users’ Guides to the Medical Literature. Reading these articles should be helpful to you in working through this worksheet as it pertains to your key article(s). Feel free to make photocopies. You can also print off additional copies from the CFPC Web Site ( www.cfpc.ca/cme/pearls/pearlsmain.asp ).
Author(s): Short title: Journal/Year/Volume/ Pages:
A.
ARE THE STUDY RESULTS VALID?
1.
Were all important options and outcomes clearly specified?
Yes No Can't tell
2.
Was an explicit and sensible process used to identify, select and combine evidence?
Yes No Can't tell
3.
Was an explicit and sensible process used to consider the relative value of different outcomes?
Yes No Can't tell
4.
Is the guideline likely to account for important recent developments?
Yes No Can't tell
5.
Has the guideline been subject to peer review and testing?
Yes No Can't tell
B.
WHAT WERE THE RESULTS?
1.
Are practical, clinically important, recommendations made?
2.
How strong are the recommendations?
3.
What is the impact of uncertainty associated with the evidence and values used in the guidelines?
C.
CAN THE RESULTS BE APPLIED TO YOUR PATIENT(S)?
1.
Is the primary objective of the guideline consistent with your objective?
Yes No Can't tell
2.
Are the recommendations applicable to your patients?
Yes No Can't tell
CONCLUSIONS The results or recommendations are valid (from A).
