JAPANESE JOURNAL OF CLINICAL ONCOLOGY Vol. 40 No. 5
May 2010
CONTENTS Review Article 377
WT1 (Wilms’ Tumor Gene 1): Biology and Cancer Immunotherapy Haruo Sugiyama Seventy-five cancer antigens including WT1 were prioritized according to many criteria, e.g. immunogenicity, and WT1 was ranked at the top of these. A new era of WT1 immunotherapy is imminent.
Original Articles Central Nervous System (CNS) 388
Over-expression of Neuroepithelial-transforming Protein 1 Confers Poor Prognosis of Patients with Gliomas Yanyang Tu, Jiang Lu, Jianfang Fu, Yizhan Cao, Guoqiang Fu, Ruirui Kang, Xiaoxi Tian and Boliang Wang This study indicates for the first time that neuroepithelial-transforming protein 1 expression pattern might be a potent marker for predicting the clinical prognosis of glioma patients.
395
Effects of Concomitant Temozolomide and Radiation Therapies on WT1-specific T-cells in Malignant Glioma Yasuyoshi Chiba, Naoya Hashimoto, Akihiro Tsuboi, Yoshihiro Oka, Ayako Murao, Manabu Kinoshita, Naoki Kagawa, Yusuke Oji, Naoki Hosen, Sumiyuki Nishida, Haruo Sugiyama and Toshiki Yoshimine Our analyses on the blood samples of patients with malignant gliomas revealed that radiation/temozolomide therapy did not significantly affect the frequency of WT1-specific T-cells.
Clinical Trials 404
Phase I and Pharmacokinetic Study of ABI-007, Albumin-bound Paclitaxel, Administered Every 3 Weeks in Japanese Patients with Solid Tumors Kazuhiko Yamada, Noboru Yamamoto, Yasuhide Yamada, Toru Mukohara, Hironobu Minami and Tomohide Tamura ABI-007 administered every 3 weeks was well tolerated up to 300 mg/m2, and the recommended dose was determined as 260 mg/m2 in consideration of efficacy, toxicities and similarity of pharmacokinetic profile in Western studies.
Gastrointestinal Surgery 412
Health-related Quality of Life in Patients with Colorectal Cancer Who Receive Oral Uracil and Tegafur plus Leucovorin Akira Tsunoda, Kentaro Nakao, Makoto Watanabe, Nobuaki Matsui and Yuko Tsunoda Adjuvant treatment with oral uracil/tegafur plus leucovorin does not negatively affect the health-related quality of life of patients with colorectal cancer.
Gynecology 420
Human Papillomavirus DNA in Plasma of Patients with HPV16 DNA-positive Uterine Cervical Cancer Takako Shimada, Naohiro Yamaguchi, Noriyuki Nishida, Kentaro Yamasaki, Kiyonori Miura, Shigeru Katamine and Hideaki Masuzaki We studied the prevalence of human papillomavirus 16 (HPV16) DNA in plasma of patients with HPV16 DNA-positive cervical cancer and its diagnostic value in these patients.
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Head & Neck 425
Induction Chemotherapy with Nedaplatin with 5-FU Followed by Intensity-modulated Radiotherapy Concurrent with Chemotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma Jijun Zheng, Ge Wang, Gary Y. Yang, Daoyuan Wang, Xizhong Luo, Chuan Chen, Zhimin Zhang, Qiong Li, Wen Xu, Zengpeng Li and Dong Wang Neoadjuvant chemotherapy with nedaplatin (NDP) and 5-fluorouracil followed by concomitant NDP and intensity-modulated radiotherapy is an effective and safe treatment for locoregionally advanced nasopharyngeal carcinoma.
Hepato-biliary and Pancreatic Medicine 432
Gemcitabine-based Cytotoxic Doublets Chemotherapy for Advanced Pancreatic Cancer: Updated Subgroup Meta-analyses of Overall Survival De-rong Xie, Qiong Yang, Deng-lin Chen, Zhi-min Jiang, Zhuo-fei Bi, Wen Ma and Yuan-dong Zhang Meta-analysis indicated a significant survival benefit when gemcitabine was either combined with capcitabine or oxaliplatin. Pancreatic cancer patients with a poor performance status had worse survival benefit from gemcitabine-based doublets.
Other Specialities 442
Development of a Predicting Tool for Survival of Terminally Ill Cancer Patients Ichinosuke Hyodo, Tatsuya Morita, Isamu Adachi, Yasuo Shima, Akitaka Yoshizawa and Kazuaki Hiraga A survival prediction tool, Japan Palliative Oncology Study-Prognostic Index (JPOS-PI), composed of five significant predictors (physician’s clinical prediction of survival, consciousness, pleural effusion, white blood cell count and lymphocyte %) was developed.
449
A Computer-assisted Model for Predicting Probability of Dying Within 7 Days of Hospice Admission in Patients with Terminal Cancer Jui-Kun Chiang, Yu-Hsiang Cheng, Malcolm Koo, Yee-Hsin Kao and Ching-Yu Chen We proposed a computer-assisted estimated probability formula for predicting dying within 7 days of hospice admission in terminal cancer patients, and the prediction accuracy was 82.3%.
Radiation Oncology 456
A Consensus-based Guideline Defining the Clinical Target Volume for Pelvic Lymph Nodes in External Beam Radiotherapy for Uterine Cervical Cancer Takafumi Toita, Tatsuya Ohno, Yuko Kaneyasu, Takashi Uno, Ryouichi Yoshimura, Takeshi Kodaira, Kazuhisa Furutani, Goro Kasuya, Satoshi Ishikura, Toshiharu Kamura and Masahiro Hiraoka The working subgroup formulated in the JCOG Radiation Therapy Study Group (RTSG) developed a consensus-based guideline on the definition of pelvic node clinical target volume and an atlas.
464
Radiation Pneumonitis Following Twice-daily Radiotherapy with Concurrent Carboplatin and Paclitaxel in Patients with Stage III Non-small-cell Lung Cancer Hiroki Kobayashi, Takashi Uno, Koichi Isobe, Naoyuki Ueno, Miho Watanabe, Rintaro Harada, Yuichi Takiguchi, Koichiro Tatsumi and Hisao Ito Cut-off values in radiotherapy dose –volume parameters for developing G2 radiation pneumonitis were identified in patients with non-small cell lung cancer who received twice-daily radiotherapy concurrently with carboplatin and paclitaxel chemotherapy.
470
Trends for the Past 10 Years and International Comparisons of the Structure of Korean Radiation Oncology Young Hoon Ji, Haijo Jung, Kwangmo Yang, Chul Koo Cho, Seong Yul Yoo, Hyung Jun Yoo, Kum Bae Kim and Mi Sook Kim This paper includes the determination of nationwide structural characteristics of radiation oncology facilities, types of radiation therapy equipment, availability of human resources and trends and comparisons with previous surveys over 10 years in Korea.
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Case Report 476
VEGF Hypersecretion as a Plausible Mechanism for Pseudo-Meigs’ Syndrome in Advanced Colorectal Cancer Yoshihisa Okuchi, Satoshi Nagayama, Yukiko Mori, Junichiro Kawamura, Shigemi Matsumoto, Takafumi Nishimura, Akihiko Yoshizawa and Yoshiharu Sakai Vascular endothelial growth factor hypersecretion from the oviducts in an ovary may play a role in the pathogenesis of clinical manifestations of pseudo-Meigs’ syndrome.
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Image of the Month and Cancer Statistics Digest
Contents of the Journal of the National Cancer Institute
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