Sunday, Day 0 (10 Dec) Young Scientist Forum @ NUS 8.30am

8.00am 8.45am 9.00am 9.45am Session 1A: Proteomics I – Biomarkers of Diseases Session Chairs: Yu-Ju CHEN & Newman SZE Venue: Level 4, Creation Room...

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Sunday, Day 0 (10 Dec) Young Scientist Forum @ NUS Registration Welcome Address Session 1 S1-1: Quantitative Phosphoproteomic Analysis Reveals System-wide Signaling Networks in Chronic Lymphocytic Leukemia (CLL) B Cells Hsin-Yi WU, Taiwan S1-2: Inferring Hydrogen-deuterium Exchange with Greater Amino Acid Resolution Using Poisson-fit Overlapping Peptides Isaac KRESSE, USA S1-3: Quantitative Proteomics Profiling of HCPs in CHO HCCF under the Supplementation of Uridine, Manganese Chloride, and Galactose by SWATH-MS Kae Hwan SIM, Singapore S1-4: Correlation Analysis of Oils Sourced from Different Shale Facies by GC and FT-ICR MS for Geochemical Maturation Yunju CHO, Korea S1-5: Experimental Validation of Comprehensive Modeling for Ultrahigh Mass Resolution Linear Time-of-Flight Mass Spectrometry Yu-Meng OU, Taiwan Morning coffee break Session 2 S2-1: Development of Portable Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometer Ko-Keng CHANG,Taiwan S2-2: Systematic Evaluation of Benzodiazepines Confirmation Assay Miao-Guo KANG, Taiwan S2-3: Is It Necessary for All Samples to Quantify 25OHD2 and 25OHD3 Using LC-MS/MS in Clinical Practice? Songlin YU, China S2-4: Comparative Analysis of Functional Components in Asian milk; Korean, Chinese, and Vietnamese Nari SEO,Korea S2-5: Highly Afficeant Quantification of Isoflavones, Formononetin and Biochanin A, and their Conjugates in Female and Male Rat Plasma using LC-ESI-MS/MS: Application in pKa/pD Study Lubna AZMI, India S2-6: Mapping Interactions of Nucleotides Metabolites with the Human Proteome using CETSA Yan Ting LIM, Singapore Lunch Session 3 S3-1: Discovery of Novel Plasma Exosome Biomarkers that Discriminates Early and Advanced NSCLC Using Quantitative Proteomics Approach Esther CHEOW, Singapore S3-2: One-step Enrichment of Protein N-terminal Peptides for N-terminal Proteomics Chih-Hsiang CHANG, Japan S3-3: Cytotoxic Activity Of Nn-32 Toxin From Indian Spectacled Cobra Venom On Human Breast Cancer Cell Lines Saurabh ATTARDE, India S3-4: Proteomic Profiling of Predictive Biomarkers for Hypoxia-activated Prodrugs in Head & Neck Squamous Cell Carcinomas Yongchuan GU, New Zealand S3-5: Multi-omics and Spatial Imaging Analysis Reveal Toxicological Mechanisms of Bisphenol F in Breast Cancer Xenografts Chao ZHAO, China S3-6: Serum Metabolomics Reveals Serotonin as a Predictor of Severe Dengue in the Early Phase of Dengue Fever Liang CUI, Singapore Afternoon coffee break Session 4 S4-1: Bis(zinc(II)-dipicolylamine) Functionalized Core-shell Microspheres Enabled Comprehensive Recognition of N-phosphopeptides Under Neutral Condition Yechen HU, China S4-2: ZBTB48 is both a telomere binding protein and a transcriptional activator Grishma RANE, Singapore S4-3: Complementary LC-MS/MS strategies Reveal Unusual Immune-Modulating N-glycosylation of Human Neutrophil Elastase Ian LOKE, Australia Career Development Forum YSF Advisors End of YSF

Monday, Day 1 (11 Dec) 8.00am 8.45am 9.00am

Registration Welcome Address & Announcements Venue: Level 2, Auditorium Plenary I The Proteome in Context Ruedi Aebersold, Switzerland Session Chair: Maxey Chung

9.45am

10.30am 11.00am

11.30am

12.00pm

12.15pm

Morning Tea + Poster Session 1

1B-1: Title: TBA Natalie AHN, USA 1B-2: Title: TBA Ganesh S. ANAND, Singapore 1B-3: Interactions between β-lactamases and β-lactamase Inhibitory Protein: Insights from Mass Spectrometric Studies Zhongping YAO, Hong Kong 1B-4: Lipid-protein Interactions at the Membrane Sites Federico TORTA, Singapore

1A-5: Early Candidate Biomarkers Found from Urine of Astrocytoma Rat before Changes on Magnetic Resonance Imaging Youhe GAO, China

12.30pm 12.45pm 1.45pm

2.00pm

Session 1B: Structural and Native Mass Spectrometry Session Chairs: Natalie AHN & Ganesh S. ANAND Venue: Level 4, Exploration Room

Session 1A: Proteomics I – Biomarkers of Diseases Session Chairs: Yu-Ju CHEN & Newman SZE Venue: Level 4, Creation Room 1A-1: Cancer Proteogenomics Paves a Pathway to Next Generation Cancer Precision Medicine Yu-Ju CHEN, Taiwan 1A-2: Dissecting the Molecular Pathology of Cancer and Dementia: Proteomic Identification of Priority Drug Targets and Diagnostic Biomarkers in the Hypoxia Pathway Newman SZE Singapore 1A-3: Identifying 19000 Protein Isoforms in a Single MS Experiment Gong ZHANG, China 1A-4: Potential Role of Heparan Sulfate 3-O Sulfotransferase 3A1 as a Tumor Suppressor in Brain Cancer Xing Fei TAN, Singapore

Sponsored Lunch Workshop by SCIEX Session 2A: Lipidomics I Session Chairs: Markus WENK & Stephen BLANKSBY Venue: Level 4, Creation Room 2A-1: Natural Variation of Blood Plasma Lipids in Healthy Asian Individuals Markus WENK, Singapore

2.30pm

2A-2: Targeted Analysis of Lipids during Different Growth Phases of Living Cyanobacteria by Easy Ambient Sonicspray Ionization Mass Spectrometry Huwei LIU, China

3.00pm

2A-3: Big Fat Back-Track: Mapping Desaturase Activity Using Ozone-Induced Dissociation Mass Spectrometry Stephen BLANKSBY, Australia

3.30pm

3.45pm 4.00pm

4.30pm 5.00pm

1B-5: Development of an Integrated Native Mass Spectrometry and Top-Down Proteomics method that Connects Sequence to Structure and Function of Marcomolecular Protein Complexes Huilin LI, France Lunch + Poster Session 2

Session 2B: Metabolomics I Sessoin Chairs: Pao-Chi LIAO & Lei ZHOU Venue: Level 4, Exploration Room 2B-1: Capillary Electrophoresis-Mass Spectrometry: A Complementary Technique to Chromatography-Mass Spectrometry for Metabolomics Guowang XU, China 2B-2: Toxicant Exposure Marker Discovery Using Different Mass Spectrometry-Based Metabolomics Data Processing Methods Pao-Chi LIAO, Taiwan

2B-3:Metabolomics in Retinal Angiogenic Diseases Lei ZHOU, Singapore

2A-4: Characterization of Metabolic Syndrome Related Lipids using a Novel Scanning Quadruple DIA Method and 2B-4: Low Dose of Emerging Organic Contaminants Exposure Reshapes the Metabolic Behaviour in Gut Microbiome SimLipid Yingdan ZHANG, Singapore Dhavalkumar Narendrabhai PATEL, Singapore 2A-5: Targeted LC/MS-based analysis of 8 Endogenous Free Fatty Acids in Human Pleural Effusion Using Surrogate 2B-5: Metabolic Reprogramming in Alzheimer's Disease Mouse Model Interfaced by Multi-risk Factors Analytes Soojin PARK, Korea Lian Yee YIP, Singapore Afternoon Tea + Poster Session 3 Session 3A: Drug Discovery and Chemical Proteomics Session 3B: Imaging Mass Spectrometry Session Chairs: Ho Jeong KWON & Qinsong LIN Session Chairs:Mitsutoshi SETOU & Richard HSU Venue: Level 4, Creation Room Venue: Level 4, Exploration Room 3A-1: Exploring New Targets of Existing Drugs via Chemical Proteomics 3B-1: Launch of International Mass Imaging Center Japan Ho Jeong KWON, Korea Mitsutoshi SETOU, Japan 3A-2: Application of Quantitative Chemical Proteomics in the Studies of Drug Mechanisms and Autophagy 3B-2: Top-Down Ambient Ionization Mass Spectrometry Imaging of Proteins Qingsong LIN, Singapore Richard HSU, Taiwan

5.30pm

3A-3: Investigation of Artemisinin’s Antimalarial and Anticancer Mechanisms with Chemical Proteomics Jigang WANG, Singapore

5.45pm

3A-4: Defining the Pharmacokinetic Boundaries of Natural Anti-Cancer Compounds using Targeted Mass Spectrometry 3B-4: Visualization of Phytochemicals in Peppercorns and Turmerics Using Microscopic MALDI-imaging MS Pei Jean TAN, Malaysia Shuichi SHIMMA, Japan

6.00pm 6.30pm

3B-3:Peptide and Glycan Mass Spectrometry Imaging as Diagnostic Tool in Cancer Research Peter HOFFMANN, Australia

End of Day 1 Welcome Reception

Tuesday, Day 2 (12 Dec)

8.00am 8.45am 9.00am

Registration Announcements Venue: Level 2, Auditorium Plenary Session II Automated Coupled LC/MS Separations Enable Gglycomics to be Integrated with Other–omics Data to Address Complexity in Biological Systems Pauline Rudd, Ireland Session Chair: Roger Beuerman

9.45am

10.30am 11.00am 11.30am

Morning Tea + Poster Session 4 Session 4A: Clinical Mass Spectrometry and Biologics Session 4B: Environmental Applications Session Chairs: David HEROLD & Xuezhi BI Session Chairs: Choon Nam ONG & Sunghwan KIM Venue: Level 4, Creation Room Venue: Level 4, Exploration Room 4B-1: Mass Spect-Metabolomics and its Potential Applications in Environmental Health Research 4A-1: Mass Spectrometry in the Clinical Laboratory Choon Nam ONG, Singapore David HEROLD, USA 4A-2: Characterization of Biotherapeutic Critical Quality Attributes and Quantitative Proteome Profiling of Bioprocess 4B-2: Application of Paper Spray Chemical Ionization and Paper Spray Ionization for Analysis of Environmental Sample in CHO Cells Using Mass Spectrometry Sunghwan KIM, Korea Xuezhi BI, Singapore 4B-3: Target Analysis and Suspect Screening of Non-ionic Surfactants in Txtiles by LC-Q-Orbitrap HRMS 4A-3: Exploring Stapled Peptide Permeability Using p53 as a Model System Xin LUO, China Anthony PARTRIDGE, Singapore 4B-4: Liquid Chromatography Derivatization: a Promising High-throughput Platform for Human Exposome Characterization Shenglan JIA, Singapore

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1.45pm 2.15pm

2.45pm 3.00pm 3.15pm 3.30pm

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4.45pm

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5.15pm 5.30pm

4A-4: Proteomics Analysis of Urinary Exosomes from Patients of Non-Small Cell Lung Cancer Thuya Win LWIN, Singapore

4B-5: Programming Water Transporter Aquaporin Z by Lipid Composition-altered Protein Dynamics Xin Shan LIM, Singapore Lunch + Poster Session 5 Sponsored Lunch Workshop by Waters Limited

Session 5A: Lipidomics II Session 5B: Mass Spectrometry Technology Advances I Session Chairs: Myeong Hee MOON & Gavin REID Session Chairs: Jentaie SHIEA & Qifeng LIN Venue: Level 4, Creation Room Venue: Level 4, Exploration Room 5A-1: New Tools in Lipidomic Analysis by LC-ESI-MS/MS 5B-1: The Next Dimension in Proteomics Myeong Hee MOON, Korea Peter B. O’CONNOR, UK 5B-2: Molecular Imaging of Metabolites and Drugs on Whole Body Skin by Ambient Mass Spectrometry 5A-2: Detailed Structural Characterization of Colon Cancer Associated Lipid Metabolism Alterations by Ultraviolet Photodissociation Tandem Mass Spectrometry Jentaie SHIEA, Taiwan Gavin REID, Australia 5A-3: Lysophosphatidylcholine and DHA Transport 5B-3: Discovery and Deciphering of the Recognition between Transplatinated DNA and Nuclear Protein Positive Cofactor PC4 by Mass Spectrometry Amaury CAZENAVE-GASSIOT, Singapore Fuyi WANG, China 5A-4: Lipid Profiling of Serum from Patients with Nonalcoholic Fatty Liver Disease Youngae JUNG, Korea 5B-4: Strategized SWATH-MS for identifying protease substrates 5A-5: Rapid identification of Isomeric Fatty Acids by Mass Spectrometry Using Novel Fixed-charge Photo-labile Derivatives Qifeng LIN, Singapore Venkateswara Reddy NARREDDULA, Australia Afternoon Tea + Poster Session 6 Session 6A: Selected Oral Presentations Session 6B: Selected Oral Presentations Session Chairs: Lei ZHOU Chair: Radoslaw SOBOTA Venue: Level 4, Creation Room Venue: Level 4, Exploration Room 6A-1: Top-down Mass Spectrometry Using BAC-PAGE 6B-1: Next Stage Glycan Markers: Isomeric Distribution Markers for Immune Disease Nobuaki TAKEMORI, Japan Jaehan KIM, Korea 6A-2: Cross Talk Between Coupling and Lipid-assisted Regulation in Transmembrane Transporter BetP 6B-2: Unraveling the Different Modes of Antibody-whole DENV Interactions that are Coupled to Serotype-specific Expansion of DENV by Hydrogen/Deuterium Exchange Mass Spectrometry Arun CHANDRAMOHAN, Singapore Xin-Xiang LIM, Singapore 6A-3: SWATH-MS Proteomics of Mangosteen Ripening 6B-3: LC-MS/MS Profiling of Human Brain Tissues by UC-ERLIC Reveals Association Between Homocitrulline and Proteinopathy in the Temporal Lobe Wan Mohd AIZAT, Malaysia Xavier GALLART-PALAU, Singapore 6B-4: Perennial Ryegrass Toxicosis: Effects Of The Indole Diterpenoid Mycotoxins On Movement And Metabolism In A Mouse Model 6A-4: Metabolomics Approach for Establishing Metabolite Fingerprint in the Djulis by High-resolution Mass Spectrometry Priyanka REDDY, Australia Hong-Jhang CHEN, Taiwan 6B-5: Image Fusion of MALDI MSI and Microscope Image for Molecular Mapping of Alzheimer’s Disease Treatment 6A-5: Precise Calculation of Ultrahigh Mass Resolving Power of Linear Time-of-Flight Mass Spectrometry by Mathematical and Physical Computation Methods Coupled Space- and Velocity- Focusing Li-En LIN, Taiwan Yi-Hong CAI, Taiwan 6A-6: Qualitative and Quantitative Analyses of Components in Overlapping GC-MS Peaks by Entropy Minimizatio Chun Kiang CHUA, Singapore 6A-7:Phylointeractomics Reconstructs Functional Evolution of Protein Binding Dennis KAPPEI, Singapore

5.45pm 5pm (tentativ 6.30pm 7.00pm - 10.3

6B-6: A Rapid LC-MS Method for Branched Chain Amino acid Separation and Analysis in Plasma Cheng Shang SEE, Singapore

6B-7: Comparative Proteomic Analysis of Circulating Tumor Exosomes in Human Saliva and Serum for Lung Cancer Hua XIAO, China End of Day 2 Societies Meeting Bus Depart for Conference Banquet Dinner Venue Conference Banquet Dinner

Wednesday, Day 3 (13 Dec)

9.00am 9.30am

10.00am 10.15am

Session 7A: Systems Biology Session Chair: Marc WILKINS Venue: Level 4, Creation Room 7A-1: The Phoenix Center and the Challenges in Proteomics Bioinformatics Jun QIN, China 7A-2: Protein Methylation and Interaction Codes in Protein Interaction Networks Marc WILKINS, Australia 7A-3: The Complicated Features of the Molecular Characteristics of the Colorectal Cancer Mouse Model Through Proteogenomics Study Siqi LIU, China

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3.45pm 4.30pm

Session 7B: Metabolomics II Session Chairs: Utpal TATU & Ying Swan HO Venue: Level 4, Exploration Room 7B-1: Ultrasensitive Quantitative Metabolomics Huiru TANG, China 7B-2: Transcriptomic,Proteomic and Metabolomic Analysis of Sexual Stage Development in Malaria Utpal TATU, India 7B-3: Metabolomics as an Enabling Tool in Bioprocess Development and Clinical Applications Ying Swan HO, Singapore 7B-4: Linking Fecal Metabolites and Gut Microbiota with Liquid Chromatography Tandem Mass Spectrometry Molecular Networking Qiang LYU, Taiwan

Morning Tea + Poster Session 7 Session 8A: Agricultural Proteomics Session Chair: Nicholas TAYLOR Venue: Level 4, Creation Room 8A-1: Proteomics Analysis of Drought Stress Response in Two Rice Varieties with Contrasting Phenotypes Paul HAYNES, Australia

Session 8B: Post-Translational/ Degenerative Protein Modifications Session Chair: Yasushi ISHIHAMA Venue: Level 4, Exploration Room 8B-1: Kinome Activity Profiling Based on Large-scale Kinase-substrate Relationships Yasushi ISHIHAMA, Japan

8A-2: Quantitative Plasma Membrane Proteome Profiling of Chickpea to Water-Deficit Revealed Role of CaDREPP1 in Stress Adaptation Niranjan CHAKRABORTY, India 8A-3: Harnessing Targeted Proteomics to Enhance Yield, Salinity Tolerance and Thermal Tolerance of Wheat Nicholas TAYLOR, Australia

8B-2: Free Radical Initiated Peptide Sequencing (FRIPS) Mass Spectrometry: Advantage in the Analysis on Posttranslational Modifications Han Bin OH, Korea 8B-3: Oxidation of Protein Tyrosine Phosphatases During Tissue Regeneration Wei WU, Netherlands

Lunch + Poster Session 8 Sponsored Lunch Workshop 1 by Thermo Fisher Scientific Inc. Sponsored Lunch Workshop 2 by Agilent Technologies Session 9A: Glycomics Session Chair: Yoshinao WADA Venue: Level 4, Creation Room 9A-1: New Methods for Glycoprotein Analysis in Pharmaceutical Development Nana KAWASAKI, Japan 9A-2: Regional Mapping of Glycosylation in Brain using Nano-LC/MS and LC/MS/MS Hyun Joo AN, Korea 9A-3: Recent Advances in Mass Spectrometry-based Glycoproteomics for Research and Diagnosis of Glycosylation Disorders Yoshinao WADA, Japan 9A-4: Innovations in Glyco-Analytics to Improve the Comprehensive Analysis of Therapeutic Glycoproteins Terry NGUYEN-KHUONG, Singapore

Session 9B: Informatics & Big Data Session Chair: HyungWon CHOI Venue: Level 4, Exploration Room 9B-1: Getting Organized: Spectral Libraries in Proteomics in the Big Data Era Henry LAM, Hong Kong 9B-2: Customized Spectral Assay Library for Untargeted Metabolomics Analysis HyungWon CHOI, Singapore 9B-3: Extraction Of Maximum Information From DIA(SWATH-MS) In A Spectral Library Free Manner Stephen TATE, Canada 9B-4: Fast Similarity Measure of SWATH-MS by Cosine Similarity of Random Pairs(CS-RP) Yan Chak LI, Hong Kong

Closing Ceremony & Awards Presentation End of Day 3