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The Journal of Biological Chemistry Published by the American Society for Biological Chemistry and Molecular Biology Founded by Christian A. Herter and sustained in part by the Christian A. Herter Memorial Fund

EDITOR-IN-CHIEF CO-EDITOR ASSOCIATE EDITORS

Martha J. Fedor Herbert Tabor Norma Allewell Judith S. Bond George M. Carman Joan W. Conaway John Exton

Paul E. Fraser Joel Gottesfeld F. P. Guengerich Richard W. Hanson Gerald W. Hart Vincent Hascall

Robert Hill John M. Kyriakis I. Robert Lehman Jerry Lingrel Kenneth E. Neet Luke O’Neill

Charles E. Samuel James Siedow Robert Simoni William Smith

Linda Spremulli F. Anne Stephenson James T. Stull Thomas Vanaman Xiao-Fan Wang

2011 EDITORIAL BOARD A Ravi Acharya Sharon H. Ackerman Robert S. Adelstein Alastair Aitken Paul D. Allen Indu S. Ambudkar Jens P. Andersen Toni M. Antalis Suneel S. Apte Hiroyuki Arai Trevor K. Archer Hiroyoshi Ariga Ifeanyi J. Arinze Elias S. Arnér Mark P. Ashe Craig S. Atwood Yossef Av-Gay Jesus Avila Francesc X. Aviles B Marie-France Bader Tamas Balla Joseph T. Barbieri Kevin Barnham Michelle C. Barton Joerg W. Bartsch Ari Barzilai Linda G. Baum Thomas A. Bayer Daniel A. Beard Donald F. Becker David M. Bedwell Vittorio Bellotti Joanne M. Belovich Eric S. Bennett Nathan A. Berger Paolo Bernardi Mark O. Bevensee Klaus Beyer Narayan R. Bhat Vera Bianchi Ricardo M. Biondi Raymond B. Birge Michael Birrer Russell Bishop William S. Blaner

Gerard Blobe Daniel F. Bogenhagen Lawrence H. Boise Stephen P. Bottomley Barbara D. Boyan Christopher A. Bradfield Dawn Brasaemle Lawrence Brass Terry M. Bricker Constance Brinckerhoff Robert M. Brosh Joseph Bryan Guojun Bu Thomas Bugge Nigel W. Bunnett Peter Burgers Thomas P. Burris C Fernando Cabral Craig E. Cameron Judith L. Campbell Wenhong Cao Xuetao Cao Ernesto Carafoli David Carling Kermit Carraway Carol Carter Bruce D. Carter Michael Cascio Roberto Cattaneo Shukti Chakravarti Charles E. Chalfant Zengyi Chang Ta-Yuan Chang Zhi-Nan Chen Yiping Chen Di Chen Eugene Chen Jie Chen Junjie Chen Xinbin Chen Ye-Guang Chen Sai-Juan Chen Genhong Cheng Yury Chernoff

Cheng-Ming Chiang John Y. Chiang Y. E. Chin Athar H. Chishti P. Boon Chock Hueng-Sik Choi David Chuang Frank C. Church G. M. Clore Robert T. Clubb Donald Coen Ronald N. Cohen Roger J. Colbran Erin Connolly Mark Cookson Terrance G. Cooper William C. Copeland Robert A. Copeland David Cortez Carmine J. Coscia François-Loic Cosset John R. Couchman David J. Craik William A. Cramer Dean Crick John P. Crow Mirek Cygler Maria Czyzyk-Krzeska D

Luciano D’Adamio Santosh R. D’Mello Wei Dai David Daleke Antonio De Flora Dennis Dean George N. DeMartino Bruce Demple Jian Ding Xinxin Ding Sheng Ding Concetta DiRusso Clark Distelhorst Henrik G. Dohlman Mark Donowitz George R. Dubyak Teresa M. Dunn

E Michael Eck Lars Eckmann Spiros Efthymiopoulos Martin Egli David J. Eide Zvulun Elazar Lisa Ellerby Ralf Erdmann Harold P. Erickson John E. Eriksson Mariano Esteban F Stephen S. Ferguson Gregg Fields Janet Finer-Moore Larry Fliegel Debora Foguel Edward A. Fon Michael Forgac Kevin Foskett Renny T. Franceschi Sharron H. Francis Thomas F. Franke Nicole FrankenbergDinkel Wayne D. Frasch Brian M. Freed Bruce A. Freeman Michael Freissmuth Wilma Friedman Serge Fuchs Yoshiaki FujiiKuriyama Catherine M. Fuller Anthony H. Futerman G Patrick Gallagher Jonas Galper Lin Gan Nicholas Geacintov Mike Geeves Anne George Peter G. Gettins Thomas W. Gettys Jonathan M. Gibbins

Carolyn W. Gibson Peter Gierschik Susan P. Gilbert Gregory M. Gilmartin Charles Glabe John H. Golbeck Roger R. Gomis Frank J. Gonzalez Joel M. Goodman Jeff P. Gorski Dixie J. Goss Yuji Goto Matthias Gotte Channe D. Gowda Barney S. Graham Gregory A. Grant Edward M. Greenfield Christof Grewer Jack Griffith Jun-Lin Guan Lorraine J. Gudas Suzanne Y. Guenette William B. Guggino Christophe Guilhot J. Silvio Gutkind Denis C. Guttridge H Andrew P. Halestrap Christine Hall John Hammer III Jing-Dong J. Han Oliver Hankinson Steven K. Hanks Tim Hardingham Alice Harmon Robert A. Harris Reuben S. Harris Akiko Hata Volker Haucke Robert Hausinger Jesse Hay Jeffrey Hayes Stanley L. Hazen Xiangwei He Xi He Wei He Lynn Heasley

Mark R. Hellmich Michael J. Hendzel John R. Hepler Brian Herman B. P. Herring Klemens Hertel N. Higgins Herbert Hildebrandt Caroline S. Hill Joseph A. Hill Mark G. Hinds Phil W. Hinds Michael Hippler Kendal D. Hirschi Arne Holmgren Todd Holyoak Andreas Holzenburg Wanjin Hong Richard Honzatko Nigel M. Hooper Bruce F. Horazdovsky Allyn C. Howlett Keith Hruska Aaron J. Hsueh Ulrich Hubscher David Y. Hui David J. Hulmes James A. Huntington James B. Hurley Ahsan Husain I Michael Ibba Nibaldo C. Inestrosa Harry Ischiropoulos Lori L. Isom Nobuhisa Iwata J Suzanne Jackowski Jean-Pierre Jacquot Enrique Jaimovich Paul Jarvis Kuan-Teh Jeang Joseph M. Jez Naihe Jing Andrzej Joachimiak Richard S. Jope

Frank Jordan Suresh K. Joseph Douglas A. Julin K Philipp J. Kahle Satish C. Kalhan Dhan V. Kalvakolanu Yibin Kang Hung-Ying Kao Jerry Kaplan Jack H. Kaplan Nikos K. Karamanos Fatah Kashanchi Byron Kemper Peter J. Kennelly Linda J. Kenney Anthony J. Kettle Roya Khosravi-Far Baek Kim Taroh Kinoshita Terri G. Kinzy Josef Kittler Thomas R. Kleyman Daniel J. Klionsky Ulla G. Knaus Peter Knight Warren Knudson Doris Koesling Sepp D. Kohlwein Bruce D. Kohorn Hisashi Koiwa John J. Kopchick Daniel Kosman Michael Koval Leslie P. Kozak Sriram Krishnaswamy Karsten Kristiansen Nicholas T. Ktistakis Thomas B. Kuhn Rakesh Kumar Tapas K. Kundu Jeff Kuret Toni M. Kutchan L Zhi-Chun Lai Dale W. Laird David G. Lambright Alex Lange Ralf Langen Ramon Latorre Matthew J. LaVoie C. M. Lawrence Stuart Le Grice Justin Lee Sam W. Lee Stephane Lemaire Stanley Lemon Thomas Leustek David Levens Lin Li Linheng Li Lei Li Guo-Min Li Min Li Ronglih Liao Xin Lin Dan Lindholm Paul Linsdell Yi Liu Xuan Liu Yang Liu Carlos Lopez-Otin Hua Lu

Kun P. Lu Richard F. Luduena Karolin Luger Joen Luirink Zhijun Luo Svetlana Lutsenko Joseph W. Lynch M Lan Ma Michael J. MacDonald Giovanni Maga Richard S. Magliozzo Patricia Maness Vincent C. Manganiello Bengt Mannervik Jennifer M. Martin Thomas F. Martin Susan A. Martinis Hisao Masai Christopher K. Mathews Glenn Matsushima Alexander V. Mazin David McConkey Hassane Mchaourab Thomas M. McIntyre Patrick A. McKee JoAnne McLaurin Steven B. McMahon Christopher R. McMaster Peter S. McPherson Robert Medcalf Gerhard Meissner James E. Melvin Anming Meng Hemmo H. Meyer Ronald Midura Jan Miernyk Marcos E. Milla A. Millar Anne-Frances Miller Laurence J. Miller Gilles Mithieux Sankar Mitra Ron Mittler Craig Mizzen Edward Mocarski Jeffery D. Molkentin Virginie Molle William R. Montfort Wouter H. Moolenaar Anna Moroni Andrew J. Morris John S. Mort Stephen J. Moss Aristidis Moustakas Gerd Multhaup Andrew W. Munro Angus S. Murphy Joanne E. MurphyUllrich Johanna Myllyharju N Hideaki Nagase Hiroyasu Nakano Anjaparavanda P. Naren Linda O. Narhi Mohandas Narla Neil Nathanson Christian C. Naus

Joseph H. Neale Marcia Newcomer Joseph T. Nickels Tommy Nilsson Jun Ninomiya-Tsuji Kazuko Nishikura Itzhak Nissim Noa Noy Asma Nusrat O Richard M. O’Brien Valerie B. O’Donnell Richard W. Olsen John S. Olson John Orlowski Paul R. Ortiz de Montellano Daniel S. Ory Yoichi Osawa Neil Osheroff Robert E. Oswald Jing-Hsiung J. Ou P Radhakrishnan Padmanabhan Krzysztof Palczewski Bruce A. Palfey Kathryn M. Partin Alberto Passi Annalisa Pastore Smita S. Patel Mats Paulsson Phillip Pekala Ann Marie Pendergast Trevor M. Penning John T. Penniston Ruth G. Perez Fred W. Perrino George Perry Lawrence M. Pfeffer Louis Philipson Aled O. Phillips Caroline C. Philpott Jean-Philippe R. Pin Paula Pitha-Rowe Stuart M. Pitson Frances M. Platt Alastair W. Poole Robert K. Poole Kirill Popov Francesc Posas Henry J. Pownall Tullio Pozzan Ambra Pozzi Paul L. Prather S. R. Price Q Jun Qin James P. Quigley Mark T. Quinn R Daniel M. Raben Ajay Rana Rajini Rao G. William Rebeck Alan Rein Dieter P. Reinhardt Ruibao Ren Jane E. Reusch Neale D. Ridgway Peter J. Roach

David D. Roberts Charles Roberts Katherine Roche Charles O. Rock Michael F. Romero Juan A. Rosado Hugh Rosen Helene Rosenberg Richard L. Rotundo Peter Rotwein Nicolas Rouhier William Royer Peter A. Rubenstein Liangyou Rui Rick Russell Tommaso Russo S Haruo Saito Lynn Y. Sakai Takao Sakai Jeremy Saklatvala Aziz Sancar Ralph D. Sanderson Massimo Santoro Michael Sattler Liliana Schaefer Jean E. Schaffer Hugo Scheer Elisabeth Schwarz Anna Seelig James R. Sellers Charles N. Serhan Edward Seto Yongfeng Shang Linda Shapiro Mark S. Shapiro Shirish Shenolikar Yun-Bo Shi Yigong Shi Yufang Shi Toru Shimizu Takao Shimizu Akiko Shiotani Michael J. Shipston Weinian Shou Hong-Bing Shu Ke Shuai Show-Ling Shyng Jerson L. Silva Symeon Siniossoglou Mikiko C. Siomi Lea Sistonen Anita Sjolander Stephen Smale Peter R. Smith Alan V. Smrcka Neil Smyth Malcolm L. Snead Peter M. Snyder Thomas Soellner Hongjun Song Byoung-Joon (BJ) Song Zhou Songyang Gina E. Sosinsky Wayne S. Sossin Sarah Spiegel Stefan Stamm Leonidas Stefanis Roland Stein David Stillman Walter Stoecker David Stokoe Judith Storch

Patrick J. Stover Stephen M. Strittmatter Vasily Studitsky Thomas Sturgill Kazuyuki Sugahara Yi M. Sun Xiao-Hong Sun Roger K. Sunahara Surachai Supattapone Witold K. Surewicz Toshiharu Suzuki Jesper Q. Svejstrup Joann Sweasy Man-Sun Sy T Hiroshi Takahashi Akihiko Takashima Fuyuhiko Tamanoi Lukas K. Tamm Raija Tammi Naoyuki Taniguchi Kelly G. Ten Hagen Kenneth K. Teng Martin Tenniswood John Tesmer Gopal Thinakaran Debbie C. Thurmond Randal S. Tibbetts Ming Tien Gabor Tigyi Marc Timmers Margaret Titus Andrew B. Tobin Marjana Tomic-Canic Jan Tommassen Ligia Toro de Stefani Tim Townes M. S. Trent William S. Trimble Bernard L. Trumpower John Turk Jerrold Turner U Dale Umetsu Sin Urban Vladimir N. Uversky Kosaku Uyeda V Hector H. Valdivia Andre J. Van Wijnen Peter Vandenabeele William E. VanNostrand Robert Vassar Willem F. Vermaas Giuseppe Villani Anders Virtanen Israel Vlodavsky Dennis R. Voelker Pia Vogel Anne Vojtek Domagoj Vucic W

Elmar Wahle John C. Wallace Jochen Walter Nancy C. Walworth Yong Wan Hong-Yang Wang En-Duo Wang

Xiao-Jing Wang Erich Wanker Stephen G. Ward Carl F. Ware Claus Wasternack Hideto Watanabe Jakob H. Waterborg Malcolm Watford Steve P. Watson Patricia C. Weber Friedemann Weber David J. Weber Nicholas J. Webster Joseph E. Wedekind Paul H. Weigel Peter A. Weil Michael A. Weiss Paul Welling Michael Welsh Ruth Welti David Wendehenne Theodore G. Wensel James Whelan Jennifer L. Whistler Sidney W. Whiteheart Jeffrey A. Whitsett Jonathan Whittaker Keith D. Wilkinson Carrie M. Wilmot Jeffrey Wilusz Dennis R. Winge David Wink Beatrice Wittenberg Benjamin Wolozin Robert K. Wong Jia-Rui Wu Jane Wu X Ting Xie Jingwu Xie Wen-Cheng Xiong Jianming Xu Ren-He Xu Tao Xu Y Takeshi Yagi Yoshihiko Yamada Toshihide Yamashita Zhen Yan Zhen Yan Yu-Chung Yang Wei Yang Yingzi Yang Xuebiao Yao Amy S. Yee Edward T. Yeh Xiao-Ming Yin Sung Ok Yoon Elton T. Young Hongtao Yu Oliver Yu Gang Yu Zhi-Min Yuan Z Ebrahim Zandi Darryl Zeldin Yi-Xin Zeng Roy Zent Qimin Zhan Luwen Zhang Ying E. Zhang Jianke Zhang

Hong Zhang Xuemin Zhang

Chen-Yu Zhang Zhong-Yin Zhang EXECUTIVE DIRECTOR

Yi Zheng Qi Zhou

Barbara A. Gordon

Pengbo Zhou Liang Zhu

Haining Zhu Yuan Zhuang

DIRECTOR OF PUBLICATIONS

Anna Zolkiewska

Nancy J. Rodnan

The Journal of Biological Chemistry ISSN 0021-9258 (print) ISSN 1083-351x (electronic)

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